Melt butter in a skillet on the stovetop or in the microwave.
Pat the tilapia fillets dry with paper towels and add them to a 9 by 13 baking dish.
Season both sides of the fillets with ¼ teaspoon of salt, ⅛ teaspoon of black pepper, the onion powder, paprika, and crushed pepper flakes.
In a small bowl, whisk together the melted butter, minced garlic, and remaining salt and pepper.
Pour the butter mixture over the seasoned tilapia ensuring that the garlic butter evenly coats the tilapia.
Place into the preheated oven and bake for 10-12 minutes until the fish flakes easily with a fork.
For a brown color on the fish, turn on the broiler and broil for 1-2 minutes.
Garnish with fresh minced parsley and/or dill and serve warm with lemon wedges.
Notes
Fish: Feel free to substitute tilapia here with other kinds of fish like flounder, red snapper, cod, halibut, or salmon.Seasoning: Use other seasonings like Italian Seasoning or Cajun seasoning on the fish.Storage: Store in an airtight container in the fridge for up to 3 days.